Endocrine Abstracts

Objective: Environmental exposure to heavy metals has affected human health. Several studies have suggested that lead increase oxidative stress and induce mitochondrial dysfunction. The objective was to determine whether there was an association between blood lead level and impaired fasting glucose (IFG) in middle-aged population.Research design and methods: This study was based on the data from the Korean National Health and Nutrition Examination Survey...

We present a rare case of Graves’ disease accompanied by pheochromocytoma, which showed normal urine and serum levels of catecholamines and their metabolites. A 45-year-old woman was referred to our hospital for the evaluation of a right adrenal incidentaloma detected by computed tomography. She was diagnosed with Graves disease at 6 months ago. Initially she got an antithyroid medication include methimazole, but her thyroid function could not control easily. So, radioact...

Aims: Postmenopause is associated with unfavorable metabolic disturbances and might be related to increase the risk of diabetes. Identification of undiagnosed diabetes and at-risk individuals may allow to initiate earlier management and to prevent diabetic complication. The objective of the present study was to determine the prevalence of undiagnosed diabetes and related risk factors in postmenopausal women.Methods: This study was based on data from the ...

Introduction: Microalbuminuria is known as a predictor of cardiovascular disease (CVD) in patients with and without diabetes, as well as the general population. The objective was to determine whether there was an association between the urinary albumin excretion and CVD risk by estimating the Framingham Risk Score (FRS) in nondiabetic middle-aged adults.Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey,...

11β-hydroxylase deficiency (11β-OHD), an autosomal recessive disorder, is the second most common cause of congenital adrenal hyperplasia. It is caused by the mutation of the CYP11B1 gene that encodes the enzyme. In classical 11β-OHD, genetic mutations of CYP11B1 lead to activity decrease or loss, but mutations in nonclassical 11β-OHD are not definite. The vast majority of mutations are associated with classic 11β-OHD, and only a few mutations causing n...

Adult-onset type II citrul this rare metabolic disease for the adult patient who exhibits mental changes and hyperammonemia without liver or brain diseases. Recently, the SLC25A13 gene, which encodes the mitochondrial aspartate glutamate carrier protein named citrin, is demonstrated to be responsible for adult-onset type II citrullinemia. While there have been multiple cases reported in the Japanese population, there is no report of adult-onset type II citrullinemia wit...

Objective: Sarcopenic obesity is a double burden for older people because it carries the cumulative risk of functional abnormality, metabolic, cardiovascular risk, and mortality compared to either sarcopenia or obesity alone. Diabetes is related to an increase in visceral adiposity and is associated with the risk of sarcopenia. The objective was to explore the association between sarcopenic obesity and diabetes and determine the associated factors with sarcopenic obesity in ol...